Comparisons between tumor burden and other prognostic factors that influence survival of patients with non‐small cell lung cancer treated with immune checkpoint inhibitors
| العنوان: | Comparisons between tumor burden and other prognostic factors that influence survival of patients with non‐small cell lung cancer treated with immune checkpoint inhibitors |
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| المؤلفون: | Tatsuya Nitawaki, Takuro Sakagami, Naoki Shingu, Yuko Sekido, Yuko Yasuda, Aiko Nakano, Kodai Kawamura, Yoshihiko Sakata, Yoshitomo Eguchi, Jumpei Hisanaga, Kazuya Ichikado, Miwa Iio |
| المصدر: | Thoracic Cancer, Vol 10, Iss 12, Pp 2259-2266 (2019) Thoracic Cancer |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, non‐small cell lung cancer, 0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Prognostic factor, Lung Neoplasms, Immune checkpoint inhibitors, Tumor burden, Immune checkpoint inhibitor, lcsh:RC254-282, Programmed cell death ligand 1, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, Biomarkers, Tumor, medicine, Humans, Molecular Targeted Therapy, prognostic biomarker, Lung cancer, Aged, Neoplasm Staging, Proportional Hazards Models, Aged, 80 and over, Receiver operating characteristic, business.industry, Proportional hazards model, Original Articles, General Medicine, Middle Aged, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Treatment Outcome, 030104 developmental biology, 030220 oncology & carcinogenesis, Original Article, Female, Non small cell, business, tumor burden |
| الوصف: | Background The use of baseline tumor burden (TB) as a prognostic factor for non‐small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs) and associations between TB and other prognostic biomarkers remain unclear. In this study, we investigated the association between TB and survival in NSCLC patients treated with ICIs in comparison with other biomarkers. Methods We retrospectively evaluated 83 NSCLC patients with ICIs administered between February 2016 and December 2018. TB was measured as the sum of the unidimensional diameters of up to five target lesions. Results The median observation period was 14.2 months. A total of 42 patients died during the follow‐up. Univariate Cox regression analysis showed that baseline TB was associated with OS. Cox regression analysis adjusted for Eastern Cooperative Oncology Group performance status (ECOG PS) alone or with addition of programmed cell death ligand 1 expression and treatment line showed that TB was a prognostic factor for OS. Using time‐dependent receiver operating characteristic curve analysis, the optimal TB cutoff for predicting OS was 12 cm, and patients were divided into a high TB group (n = 21) and a low TB group (n = 62). The low TB group achieved significantly longer OS than the high TB group (median OS: 18.5 months, [95% CI = 11.7‐not reached] vs. 2.3 months [95% CI = 1.3–2.9], P |
| تدمد: | 1759-7714 1759-7706 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20055af3f9dbba302975d5fe1162123fTest https://doi.org/10.1111/1759-7714.13214Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....20055af3f9dbba302975d5fe1162123f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597714 17597706 |
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