Orchestration of lymphocyte chemotaxis by mitochondrial dynamics
| العنوان: | Orchestration of lymphocyte chemotaxis by mitochondrial dynamics |
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| المؤلفون: | Luca Scorrano, Antonella Viola, Silvia Campello, Monica Bettella, Santos Mañes, Rosa Ana Lacalle |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | The Rockefeller University Press, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Mitochondrion, Jurkat cells, Membrane Fusion, Microtubules, Mitochondrial Membrane Transport Proteins, GTP Phosphohydrolases, Jurkat Cells, Adenosine Triphosphate, Immunology and Allergy, Lymphocytes, Phosphorylation, Membrane Potential, Mitochondrial, Microscopy, Microscopy, Confocal, biology, Chemotaxis, Nocodazole, Articles, Androstadienes, Chemotactic Factors, Chemotaxis, Leukocyte, HL-60 Cells, Humans, Luminescent Proteins, Membrane Transport Proteins, Microtubule-Associated Proteins, Mitochondria, Mitochondrial Proteins, Myosin Light Chains, Oligomycins, Organelle Shape, Pertussis Toxin, Pyrones, Transfection, Mitochondrial, Cell biology, mitochondrial fusion, Confocal, Mitochondrial fission, Wortmannin, Dynamins, Settore BIO/06, Immunology, Membrane Potential, Article, Lymphocyte chemotaxis, Mitochondrial membrane transport protein, Leukocyte, Cytoplasm, biology.protein |
| الوصف: | Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial and functional asymmetries. Mitochondria are highly dynamic organelles that distribute in the cytoplasm to meet specific cellular needs, but whether this is essential to lymphocyte functions is unknown. We show that mitochondria specifically concentrate at the uropod during lymphocyte migration by a process involving rearrangements of their shape. Mitochondrial fission facilitates relocation of the organelles and promotes lymphocyte chemotaxis, whereas mitochondrial fusion inhibits both processes. Our data substantiate a new role for mitochondrial dynamics and suggest that mitochondria redistribution is required to regulate the motor of migrating cells. |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c31e777ff3f1fdd262d3a4fe777c8dTest http://europepmc.org/articles/PMC2118173Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16c31e777ff3f1fdd262d3a4fe777c8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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