Motor Recovery and Axonal Plasticity With Short-Term Amphetamine After Stroke
| العنوان: | Motor Recovery and Axonal Plasticity With Short-Term Amphetamine After Stroke |
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| المؤلفون: | Gwendolyn L. Kartje, Shih-Yen Tsai, Juan Ortega, Veronica Guillen, William A. Wolf, Catherine M. Papadopoulos |
| المصدر: | Stroke. 40:294-302 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Movement disorders, Growth Cones, Efferent Pathways, Drug Administration Schedule, Article, Forelimb, Neuroplasticity, medicine, Animals, Rats, Long-Evans, Amphetamine, Stroke, Paresis, Advanced and Specialized Nursing, Movement Disorders, Neuronal Plasticity, business.industry, Amphetamines, Motor Cortex, Infarction, Middle Cerebral Artery, Recovery of Function, medicine.disease, Nerve Regeneration, Rats, Disease Models, Animal, Treatment Outcome, medicine.anatomical_structure, Anesthesia, Central Nervous System Stimulants, Motor recovery, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug, Motor cortex |
| الوصف: | Background and Purpose— There is considerable debate regarding the efficacy of amphetamine to facilitate motor recovery after stroke or experimental brain injury. Different drug dosing and timing schedules and differing physical rehabilitation strategies may contribute to outcome variability. The present study was designed to ascertain (1) whether short-term amphetamine could induce long-term functional motor recovery in rats after an ischemic lesion modeling stroke in humans; (2) how different levels of physical rehabilitation interact with amphetamine to enhance forelimb-related functional outcome; and (3) whether motor improvement was associated with axonal sprouting from intact corticoefferent pathways originating in the contralesional forelimb motor cortex. Methods— After permanent middle cerebral artery occlusion, rats received vehicle or amphetamine during the first postoperative week (2 mg/kg, subcutaneously on Postoperative Days 2, 5, and 8). In both treatment groups, separate cohorts of rats were exposed to different levels of “physical rehabilitation” represented by a control environment, enriched environment, or enriched environment with additional sessions of focused activity. Skilled forelimb performance was assessed using the forelimb reaching task and ladder rung walk test. Anterograde tracing with biotinylated dextran amine was used to assess new fiber outgrowth to denervated motor areas. Results— All treatment groups showed significant motor improvement as compared with control-housed, vehicle-treated animals. However, animals housed in an enriched environment that received amphetamine paired with focused activity sessions performed significantly better than any other treatment group and was the only group to achieve complete motor recovery (ie, reached preoperative performance) by 8 weeks. This recovery was associated with axonal sprouting into deafferentated subcortical areas from contralesional projection neurons. Conclusions— This study suggests that, after stroke, short-term pairing of amphetamine with sufficiently focused activity is an effective means of inducing long-term improvement in forelimb motor function. The anatomic data suggests that corticoefferent plasticity in the form of axonal sprouting contributes to the maintenance of motor recovery. |
| تدمد: | 1524-4628 0039-2499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1dfa34398430f4ecbbd7f236587503Test https://doi.org/10.1161/strokeaha.108.519769Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea1dfa34398430f4ecbbd7f236587503 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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