دورية أكاديمية
The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
| العنوان: | The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy |
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| المؤلفون: | De Bernardo, Maddalena, Diana, Francesco, Gioia, Marco, DE LUCA, Martina, Tepedino , Maria Francesca, PELLECCHIA, MARIA TERESA |
| المساهمون: | Institut Català de la Salut, De Bernardo M, Gioia M, De Luca M Eye Unit, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Fisciano, Italy. Diana F Neuroradiology Unit, University Hospital San Giovanni di Dio e Ruggi d’Aragona, Salerno, Italy. Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Tepedino MF, Pellecchia MT Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Fisciano, Italy, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Coroide, Steele-Richardson-Olszewski, Síndrome de, Imatgeria per ressonància magnètica, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Supranuclear Palsy, Progressive, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging, ANATOMY::Sense Organs::Eye::Uvea::Choroid, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::parálisis supranuclear progresiva, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética, ANATOMÍA::órganos de los sentidos::ojo::úvea::coroides |
| الوصف: | Choroid; Optical coherence tomography; Retina ; Coroide; Tomografia de coherència òptica; Retina ; Coroides; Tomografía de coherencia óptica; Retina ; Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. Recently, several retinal layers in PSP compared to healthy controls. were found to be thinner. However, no studies evaluating the correlation between retinal layers and cerebral white matter changes, nor eventual choroidal changes in PSP, have been conducted so far. The goals of the present study were to explore potential differences in choroidal structure between PSP and healthy controls, and to describe the relationship between retinal layers’ thickness and volume, using spectral-domain optical coherence tomography (SD-OCT) and age-related white matter change scores (ARWMC) using magnetic resonance imaging (MRI) of the brain. Choroidal structures of 26 PSP patients and 26 healthy controls using standard SD-OCT with an enhanced depth imaging (EDI) approach were analyzed; then, retinal the structures of 16 of these PSP patients using standard SD-OCT were examined; finally, the same patients underwent brain MRI, and their cerebral white matter changes were calculated. Non-statistically significant differences between PSP patients’ and healthy controls’ choroidal structure were found. On the contrary, PSP patients’ inner retinal layers (INR), retinal pigmented epithelium (RPE) and all retinal layers’ thicknesses in the macular region were found to be significantly correlated with ARWMC, independently from age and axial length (AL). PSP patients’ neurological alterations go hand in hand with retinal ones, independently from age and axial length. Our results suggest a mutual relationship between cerebral and retinal structure pathological alterations. On the other hand, no significant differences in the choroidal evaluation compared to healthy controls have been found. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| العلاقة: | Journal of Clinical Medicine;12(20); https://doi.org/10.3390/jcm12206671Test; De Bernardo M, Diana F, Gioia M, De Luca M, Tepedino MF, Pellecchia MT, et al. The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy. J Clin Med. 2023 Oct 22;12(20):6671.; https://hdl.handle.net/11351/10759Test; 001089416400001 |
| DOI: | 10.3390/jcm12206671 |
| الإتاحة: | https://doi.org/10.3390/jcm12206671Test https://hdl.handle.net/11351/10759Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8C348D3D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm12206671 |