Incidence, characteristics, and outcome of COVID-19 in patients on liver transplant program: a retrospective study in the north of Iran
| العنوان: | Incidence, characteristics, and outcome of COVID-19 in patients on liver transplant program: a retrospective study in the north of Iran |
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| المؤلفون: | Pirouz Samidoust, Mohammad Taghi Ashoobi, R. Navid Talemi, M.S. Esmaeili Delshad, K. Mojtahedi, Aryan Samidoust, S. Jahangiri |
| المصدر: | New Microbes and New Infections, Vol 44, Iss, Pp 100935-(2021) New Microbes and New Infections |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, AST, aspartate aminotransferase, Disease, Infectious and parasitic diseases, RC109-216, Liver transplantation, Iran, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Microbiology, ACE2, angiotensin-converting enzyme-2, Internal medicine, medicine, HDL, High-density lipoprotein, liver transplant recipients, DBIL, direct bilirubin, CTscan, computed tomography scan, CDC, Centers for Disease Control, In patient, TBIL, total bilirubin, NSAIDs, nonsteroidal anti-inflammatory drugs, HBV, Hepatitis B, NASH, Non-alcoholic steatohepatitis, Liver injury, liver transplantation, business.industry, SARS-CoV-2, Incidence (epidemiology), COVID-19, Retrospective cohort study, medicine.disease, PSC, primary sclerosing cholangitis, Infectious Diseases, Original Article, SD, standard deviation, business, TBIL |
| الوصف: | The risk of severe coronavirus disease-2019 (COVID-19) disease seems to be higher in individuals with solid organ transplantation. Therefore, the purpose of the present research is to investigate the incidence of COVID-19 and laboratory data and epidemiologic factors in liver transplant recipients and the patients on the waiting list for liver transplantation. In this study, we evaluated the records of patients on the waiting list for liver transplantation and of recipients of a liver transplant. Demographic data, underlying disease, history of drug use and participants' outcomes were collected. The diagnosis of SARS-CoV-2 infection for all patients was confirmed using a nasopharyngeal swab specimen with real-time RT-PCR. During the study period, 172 patients were enrolled, among whom 85 patients (49.4%) were on the waiting list for liver transplantation, and 87 patients (50.6%) were recipients of a liver transplant. Out of them, 10 (5.8%) had a positive result for SARS-CoV-2. Of these patients, 7.05% (6/85) and 4.6% (4/87) of patients on the waiting list and recipients of liver transplants were positive for SARS-CoV-2, respectively. Patients on the waiting list with COVID-19 infection had a higher median of albumin, ALT, AST, TBIL, DBIL, HDL and LDL value. In summary, the incidence of COVID-19 in liver transplant patients was slightly higher. The existence of underlying liver diseases should be well known as one of the poor predictive factors for worse outcomes in patients with COVID-19. So, comparative studies are recommended to identify risk factors for COVID-19 in patients with liver injury. |
| اللغة: | English |
| تدمد: | 2052-2975 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990cdcfd9e698bf3a0e2b7d10e9e6b75Test http://www.sciencedirect.com/science/article/pii/S2052297521000998Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....990cdcfd9e698bf3a0e2b7d10e9e6b75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20522975 |
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