A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling
| العنوان: | A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling |
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| المؤلفون: | Emily E. Noble, Ted M. Hsu, Scott E. Kanoski, Matthew R. Hayes, Joel D. Hahn, David J. Reiner, Clarissa M. Liu, Alyssa M. Cortella, Vaibhav R. Konanur, Andrea N. Suarez |
| المصدر: | Molecular Psychiatry. 23:1555-1565 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Prefrontal Cortex, Hippocampus, Hippocampal formation, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Eating, 03 medical and health sciences, Cellular and Molecular Neuroscience, Glutamatergic, Neural Pathway, 0302 clinical medicine, Glucagon-Like Peptide 1, Neural Pathways, Animals, Prefrontal cortex, Receptor, CA1 Region, Hippocampal, Molecular Biology, Motivation, digestive, oral, and skin physiology, Feeding Behavior, Rats, Psychiatry and Mental health, 030104 developmental biology, Food, NMDA receptor, Psychopharmacology, Psychology, Neuroscience, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | The hippocampus and the medial prefrontal cortex (mPFC) are traditionally associated with regulating memory and executive function, respectively. The contribution of these brain regions to food intake control, however, is poorly understood. The present study identifies a novel neural pathway through which monosynaptic glutamatergic ventral hippocampal field CA1 (vCA1) to mPFC connectivity inhibits food-motivated behaviors through vCA1 glucagon-like peptide-1 receptor (GLP-1R). Results demonstrate that vCA1-targeted RNA interference-mediated GLP-1R knockdown increases motivated operant responding for palatable food. Chemogenetic disconnection of monosynaptic glutamatergic vCA1 to mPFC projections using designer receptors exclusively activated by designer drugs (DREADDs)-mediated synaptic silencing ablates the food intake and body weight reduction following vCA1 GLP-1R activation. Neuropharmacological experiments further reveal that vCA1 GLP-1R activation reduces food intake and inhibits impulsive operant responding for palatable food via downstream communication to mPFC NMDA receptors. Overall these findings identify a novel neural pathway regulating higher-order cognitive aspects of feeding behavior. |
| تدمد: | 1476-5578 1359-4184 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b73f50457d78c4aba52b8d9c6c7feb8Test https://doi.org/10.1038/mp.2017.91Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b73f50457d78c4aba52b8d9c6c7feb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765578 13594184 |
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