Protective role of Convolvulus pluricaulis on lipid abnormalities in high-fat diet with low dose streptozotocin-induced experimental rat model
| العنوان: | Protective role of Convolvulus pluricaulis on lipid abnormalities in high-fat diet with low dose streptozotocin-induced experimental rat model |
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| المؤلفون: | Kripa Shanker Kasudhan, Gaurav Garg, Alka Bhatia, Smita Pattanaik, Amol N Patil, Rohit Manoj Kumar |
| المصدر: | Journal of Ayurveda and Integrative Medicine, Vol 11, Iss 4, Pp 426-431 (2020) Journal of Ayurveda and Integrative Medicine |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, 0211 other engineering and technologies, 02 engineering and technology, Convolvulus pluricaulis, 03 medical and health sciences, Hypolipidemia, 0302 clinical medicine, Internal medicine, Diabetes mellitus, 021105 building & construction, Drug Discovery, Hyperlipidemia, medicine, lcsh:Miscellaneous systems and treatments, biology, Streptozotocin, business.industry, High fat diet, Insulin, Low dose, lcsh:RZ409.7-999, medicine.disease, biology.organism_classification, 030205 complementary & alternative medicine, Endocrinology, Complementary and alternative medicine, Original Research Article (Experimental), business, Glipizide, medicine.drug |
| الوصف: | Background The methanolic extract of Convolvulus pluricaulis had earlier shown lipid lowering activity in Triton induced reversible hyperlipidemia model, but, the hypolipidemic activity in irreversible models and hypoglycaemic activity are not investigated so far. Objective This study was designed to validate the lipid and glucose-lowering actions of C. pluricaulis methanolic extract (CPME) by using ingredients from the Indian diet for induction of hyperlipidemia and diabetes on experimental rats. Materials and methods Experimental animals were divided into four groups having six animals in each group (n = 6). Animals of Group I II, III and IV received - no treatment, 0.9% NaCl, Glipizide (GPZ) 5 mg/kg and CPME 400 mg/kg once daily for two weeks respectively. Animals of all groups except group I were fed a high fat-based Indian diet for 21 days followed by a single STZ (35 mg/kg) i.p. administration in model induction phase. Afterwards, animals were sacrificed, and the pancreas was dissected for histological changes, and blood was collected for measuring lipid parameters, FBS, insulin levels, and HOMA scores. Results CPME significantly ameliorate the lipid abnormalities in HFD-STZ-treated experimental model (p 0.05) as compared to experimental group while, GPZ showed protective effect on both lipid abnormalities and hyperglycemia by modulating the levels of lipid parameters and insulin respectively. Conclusion In conclusion, the study confirm that CPME possesses significant hypolipidemic activity but fails to reverse the hyperglycaemia developed in diabetic rats. Graphical abstract Image 1 |
| تدمد: | 0975-9476 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063926f47e7fc771296ae556e8fba493Test https://doi.org/10.1016/j.jaim.2020.06.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....063926f47e7fc771296ae556e8fba493 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09759476 |
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