Obstacles and opportunities in the prevention and treatment of HBV-related hepatocellular carcinoma
| العنوان: | Obstacles and opportunities in the prevention and treatment of HBV-related hepatocellular carcinoma |
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| المؤلفون: | Yong Liao |
| المصدر: | Genes & Diseases Genes and Diseases, Vol 7, Iss 3, Pp 291-298 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cirrhosis, HCC, Hepatocellular carcinoma, lcsh:QH426-470, Anti-viral therapy, medicine.disease_cause, Biochemistry, Article, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, NA, Nucleos(t)ide analogue, HBV, Hepatitis B virus, medicine, Intensive care medicine, Molecular Biology, Genetics (clinical), NAFLD, Non-alcoholic fatty liver diseases, DAA, Direct antiviral agents, Hepatitis, Hepatitis B virus, NASH, Non-alcoholic steatohepatitis, lcsh:R5-920, AFP, alpha-fetoprotein, business.industry, Incidence (epidemiology), Cell Biology, Chronic inflammation, medicine.disease, lcsh:Genetics, OS, Overall Survival, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Liver cirrhosis, 030211 gastroenterology & hepatology, lcsh:Medicine (General), Liver cancer, Primary liver cancer, business, cccDNA, covalently closed circular DNA |
| الوصف: | Despite the tremendous progresses toward our understanding of the mechanisms of how liver cancer was developed, the therapeutic outcomes of liver cancer in the clinic have very limited improvement within the past three decades or so. In addition, both the incidence and mortality of liver cancer worldwide are not dropping, but increasing steadily, in the last decade. Thus, it is time for us to rethink what has been wrong and how could we do better in the upcoming years, in order to achieve our goal of improving the therapeutic outcomes of patients with liver cancer in the clinic, and at the meantime, effectively reducing the incidence of liver cancer by blocking malignant transformation of hepatocytes from chronic viral infection. This is also one of the main reasons why we try to organize this special issue on primary liver cancer in the journal of Genes & Diseases. In this perspective, I will summarize the major obstacles confronted with in the prevention and management of patients with chronic hepatitis B infection and subsequent development of liver cirrhosis and liver cancer. Next, I will delineate the pitfalls and underlying mechanisms of why the current anti-viral strategies and therapeutic agents are not as effective as one expected in terms of successful reduction or prevention chronic hepatitis B infection associated liver cirrhosis and liver cancer. I will then provide my personal perspectives on potential approaches and strategies for effective prevention and management of hepatitis B-related liver cancer. |
| تدمد: | 2352-3042 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9731fa8806b901e4c50ab6acd9c09c6Test https://pubmed.ncbi.nlm.nih.gov/32884983Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9731fa8806b901e4c50ab6acd9c09c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523042 |
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