التفاصيل البيبلوغرافية
| العنوان: |
Soluble Factors Secreted by T Cells Promote β-Cell Proliferation. |
| المؤلفون: |
Dirice, Ercument, Kahraman, Sevim, Wenyu Jiang, El Ouaamari, Abdelfattah, De Jesus, Dario F., Teo, Adrian K. K., Jiang Hu, Kawamori, Dan, Gaglia, Jason L., Mathis, Diane, Kulkarni, Rohit N. |
| المصدر: |
Diabetes; Jan2014, Vol. 63 Issue 1, p188-202, 15p, 3 Color Photographs, 1 Chart, 4 Graphs |
| مصطلحات موضوعية: |
PANCREATIC beta cells, ISLANDS of Langerhans, T cells, CELL growth, TYPE 1 diabetes, BLOOD sugar, CELL proliferation |
| مستخلص: |
Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading to insulin deficiency. Although infiltrating immune cells are traditionally considered to negatively impact β-cells by promoting their death, their contribution to proliferation is not fully understood. Here we report that islets exhibiting insulitis also manifested proliferation of β-cells that positively correlated with the extent of lymphocyte infiltration. Adoptive transfer of diabetogenic CD4+ and CD8+ T cells, but not B cells, selectively promoted β-cell proliferation in vivo independent from the effects of blood glucose or circulating insulin or by modulating apoptosis. Complementary to our in vivo approach, coculture of diabetogenic CD4+ and CD8+ T cells with NOD.RAG1-/- islets in an in vitro transwell system led to a dose-dependent secretion of candidate cytokines/chemokines (interleukin-2 [IL-2], IL-6, IL-10, MIP-1α, and RANTES) that together enhanced β-cell proliferation. These data suggest that soluble factors secreted from T cells are potential therapeutic candidates to enhance β-cell proliferation in efforts to prevent and/or delay the onset of type 1 diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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