التفاصيل البيبلوغرافية
| العنوان: |
Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression. |
| المؤلفون: |
Chen, Lei, Li, Zong-yang, Xu, Sui-yi, Zhang, Xie-jun, Zhang, Yuan, Luo, Kun, Li, Wei-ping |
| المصدر: |
Cellular & Molecular Neurobiology; Jan2016, Vol. 36 Issue 1, p113-120, 8p |
| مصطلحات موضوعية: |
MICRORNA, ONCOGENES, TUMOR suppressor genes, GLIOMAS, CELL proliferation, CELL migration, TUMOR growth, NEOVASCULARIZATION |
| مستخلص: |
MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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