Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma
| العنوان: | Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma |
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| المؤلفون: | Lawrence H. Boise, Mala Shanmugam |
| المصدر: | Cancer Research. 79:2102-2103 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Stromal cell, CD38, Mitochondrion, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Tumor Microenvironment, medicine, Humans, Multiple myeloma, Tumor microenvironment, Chemistry, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, Mitochondria, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, Bone marrow, Stromal Cells, Multiple Myeloma, Intracellular |
| الوصف: | Marlein and colleagues demonstrate in multiple myeloma, bone marrow stromal cells transfer mitochondria to myeloma cells to increase cellular respiration, resulting in increased proliferation. The intercellular transfer occurs through the formation of tunneling nanotubes that connect the myeloma cell to the stromal cell and is dependent on surface CD38 expression on myeloma cells. CD38 is an important therapeutic target in myeloma, therefore, regulation of myeloma metabolism may play a role in the activity of this therapeutic approach. The study reinforces the importance of intercellular interactions in the tumor microenvironment and sheds new light on the control of metabolism in myeloma. See related article by Marlein et al., p. 2285 |
| تدمد: | 1538-7445 0008-5472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c359811252ed7f030209dfde6d45b894Test https://doi.org/10.1158/0008-5472.can-19-0500Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c359811252ed7f030209dfde6d45b894 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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