Impact of postoperative complications on long-term survival following surgery for T4 colorectal cancer
| العنوان: | Impact of postoperative complications on long-term survival following surgery for T4 colorectal cancer |
|---|---|
| المؤلفون: | Francesco Esposito, Eylon Lahat, Chady Salloum, Michael Osseis, Chetana Lim, Toufic Moussallem, Liliana Fuentes, Alexandre Doussot, Daniel Azoulay |
| المصدر: | BMC Surgery BMC Surgery, Vol 18, Iss 1, Pp 1-11 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Survival, Colorectal cancer, lcsh:Surgery, Locally advanced, 030230 surgery, Resection, 03 medical and health sciences, Postoperative complications, 0302 clinical medicine, Recurrence, Long term survival, Overall survival, Medicine, Humans, In patient, Colorectal, Aged, Retrospective Studies, Aged, 80 and over, business.industry, lcsh:RD1-811, General Medicine, Length of Stay, Middle Aged, medicine.disease, Surgery, 030220 oncology & carcinogenesis, Population study, Female, T4 tumors, business, Colorectal Neoplasms, Hospital stay, Research Article |
| الوصف: | Background Postoperative complications (POCs) after the resection of locally advanced colorectal cancer (CRC) may influence adjuvant treatment timing, outcomes, and survival. This study aimed to evaluate the impact of POCs on long-term outcomes in patients surgically treated for T4 CRC. Methods All consecutive patients who underwent the resection of T4 CRC at a single centre from 2004 to 2013 were retrospectively analysed from a prospectively maintained database. POCs were assessed using the Clavien-Dindo classification. Patients who developed POCs were compared with those who did not in terms of recurrence-free survival (RFS) and overall survival (OS). Results The study population comprised 106 patients, including 79 (74.5%) with synchronous distant metastases. Overall, 46 patients (43%) developed at least one POC during the hospital stay, and of those patients, 9 (20%) had severe complications (Clavien-Dindo ≥ grade III). POCs were not associated with OS (65% with POCs vs. 69% without POCs; p = 0.72) or RFS (58% with POCs vs. 70% without POCs; p = 0.37). Similarly, POCs did not affect OS or RFS in patients who had synchronous metastases at diagnosis compared with those who did not. Conclusions POCs do not affect the oncological course of patients subjected to the resection of T4 CRC, even in cases of synchronous metastases. Electronic supplementary material The online version of this article (10.1186/s12893-018-0419-y) contains supplementary material, which is available to authorized users. |
| تدمد: | 1471-2482 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2b097a3492efc759b6dca560c58d86Test https://pubmed.ncbi.nlm.nih.gov/30332994Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba2b097a3492efc759b6dca560c58d86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712482 |
|---|