التفاصيل البيبلوغرافية
| العنوان: |
Immunological Status of Bladder Cancer Patients Based on Urine Leukocyte Composition at Radical Cystectomy. |
| المؤلفون: |
Cantó, Elisabet, Faba, Óscar Rodríguez, Zamora, Carlos, Mulet, Maria, Garcia-Cuerva, Maria Soledad, Palomino, Ana, Anguera, Georgia, Breda, Alberto, Maroto, Pablo, Vidal, Sílvia |
| المصدر: |
Biomedicines; Sep2021, Vol. 9 Issue 9, p1125-1125, 1p |
| مصطلحات موضوعية: |
BLADDER cancer, URINE, BLOOD circulation, LEUCOCYTES, CANCER patients |
| مستخلص: |
Background: Bladder cancer (BC) is the ninth most common malignancy worldwide, with high rates of recurrence. The use of urine leukocyte composition at the time of radical cystectomy (RC) as a marker for the study of patients' immunological status and to predict the recurrence of muscle-invasive bladder cancer (MIBC) has received little attention. Methods: Urine and matched peripheral blood samples were collected from 24 MIBC patients at the time of RC. Leukocyte composition and expression of PD-L1 and PD-1 in each subpopulation were determined by flow cytometry. Results: All MIBC patients had leukocytes in urine. There were different proportions of leukocyte subpopulations. The expression of PD-L1 and PD-1 on each subpopulation differed between patients. Neoadjuvant chemotherapy (NAC), smoking status, and the affectation of lymph nodes influenced urine composition. We observed a link between leukocytes in urine and blood circulation. Recurrent patients without NAC and with no affectation of lymph nodes had a higher proportion of lymphocytes, macrophages, and PD-L1+ neutrophils in urine than non-recurrent patients. Conclusions: Urine leukocyte composition may be a useful tool for analyzing the immunological status of MIBC patients. Urine cellular composition allowed us to identify a new subgroup of LN− patients with a higher risk of recurrence. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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