Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus
| العنوان: | Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus |
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| المؤلفون: | Sang Cheol Bae, Seung-Hoon Baek, Tae-Ho Kim, Shin-Yoon Kim, Sang-Han Lee |
| المصدر: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Genetic Markers, Male, 0301 basic medicine, Article Subject, Complement receptor 2, lcsh:Medicine, chemical and pharmacologic phenomena, Single-nucleotide polymorphism, Complement receptor, Bioinformatics, Polymorphism, Single Nucleotide, Inflammatory bowel disease, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Femur Head Necrosis, Risk Factors, medicine, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, skin and connective tissue diseases, Genetic Association Studies, Genetic association, Autoimmune disease, General Immunology and Microbiology, business.industry, lcsh:R, Haplotype, General Medicine, medicine.disease, 030104 developmental biology, Haplotypes, Rheumatoid arthritis, Immunology, Female, Receptors, Complement 3d, business, Research Article |
| الوصف: | Osteonecrosis of the femoral head (ONFH) is a complex and multifactorial disease that is influenced by a number of genetic factors in addition to environmental factors. Some autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), are associated with the development of ONFH. Complement receptor type 2 (CR2) is membrane glycoprotein which binds C3 degradation products generated during complement activation.CR2has many important functions in normal immunity and is assumed to play a role in the development of autoimmune disease. We investigated whetherCR2gene polymorphisms are associated with risk of ONFH in SLE patients. Eight polymorphisms in theCR2gene were genotyped using TaqMan™assays in 150 SLE patients and 50 ONFH in SLE patients (SLE_ONFH). The association analysis of genotyped SNPs and haplotypes was performed with ONFH. It was found that three SNPs, rs3813946 in 5′-UTR (untranslated region), rs311306 in intron 1, and rs17615 in exon 10 (nonsynonymous SNP; G/A, Ser639Asn) of theCR2gene, were associated with an increased risk of ONFH under recessive model (Pvalues; 0.004~0.016). Haplotypes were also associated with an increased risk (OR; 3.73~) of ONFH in SLE patients. These findings may provide evidences thatCR2contributes to human ONFH susceptibility in Korean SLE patients. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef825af8edc8a659a0728c6ed232f0e2Test https://doi.org/10.1155/2016/9208035Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ef825af8edc8a659a0728c6ed232f0e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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