Alfy-dependent elimination of aggregated proteins by macroautophagy
| العنوان: | Alfy-dependent elimination of aggregated proteins by macroautophagy |
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| المؤلفون: | Ai Yamamoto, Anne Simonsen |
| المصدر: | Autophagy. 7:346-350 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Proteolysis, ATG5, Autophagy-Related Proteins, Biology, Protein degradation, Models, Biological, Neuroprotection, Mice, Protein structure, Autophagy, medicine, Animals, Humans, Protein Structure, Quaternary, Molecular Biology, Transcription factor, Adaptor Proteins, Signal Transducing, medicine.diagnostic_test, Membrane Proteins, Cell Biology, Protein Structure, Tertiary, Article Addendum, Cell biology, Membrane protein, HeLa Cells, Transcription Factors |
| الوصف: | Degradation of different cargo by macroautophagy is emerging as a highly selective process which relies upon specific autophagy receptors and adapter molecules that link the cargo with the autophagic molecular machinery. We have recently reported that the large phsophatidylinositol-3-phosphate (PtdIns(3)P)-binding protein Alfy (Autophagy-linked FYVE protein) is required for selective degradation of aggregated proteins. Although depletion of Alfy inhibits Atg5-dependent aggregate degradation, overexpression of Alfy results in Atg5-dependent aggregate clearance and neuroprotection. Alfy-mediated degradation requires the ability of Alfy to directly interact with Atg5. This ability to interact with the core autophagic machinery may cause Alfy to diminish the responsiveness to nonselective autophagic degradation as measured by long-lived protein degradation. Thus, increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others. |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27848ddea230669d16c51f8406a12dadTest https://doi.org/10.4161/auto.7.3.14234Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....27848ddea230669d16c51f8406a12dad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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