المؤلفون: Maja Baretić, Ivana Kraljević, Ivana Pavlić Renar

المصدر: Acta Clinica Croatica, Vol 55., Iss 1., Pp 93-98 (2016)

مصطلحات موضوعية: Diabetes mellitus, type 1 – complications, Hypoglycemia prevention and control, Insulin – pump administration and dosage, Insulin infusion systems, Insulin pump, Adult, Medicine

الوصف: The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.

وصف الملف: electronic resource

العلاقة: https://hrcak.srce.hr/file/237763Test; https://doaj.org/toc/0353-9466Test; https://doaj.org/toc/1333-9451Test

الوصول الحر: https://doaj.org/article/3657e5ca2a994117b06113019911b5e1Test

المؤلفون: Vesna Kušec, Ivana Pavlić-Renar, Velimir Altabas, Valentina Uroić, Maja Baretić

المصدر: Acta Clinica Croatica

مصطلحات موضوعية: Adult, Male, 030213 general clinical medicine, 0209 industrial biotechnology, Taste, medicine.drug_class, medicine.medical_treatment, Glucagon-like peptide 1, Food preferences, Cross-over studies, Double-blind method, Physiology, 02 engineering and technology, Placebo, 03 medical and health sciences, Food Preferences, 020901 industrial engineering & automation, 0302 clinical medicine, Sex Factors, Double-Blind Method, Tongue, Glucagon-Like Peptide 1, medicine, Humans, Original Scientific Papers, Saline, Cross-Over Studies, business.industry, digestive, oral, and skin physiology, Taste Perception, General Medicine, Middle Aged, Crossover study, Glucagon-like peptide-1, medicine.anatomical_structure, Estrogen, Female, business, Hormone

الوصف: SUMMARY Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue. The aim of the study was to find out how gut hormone glucagon-like peptide-1 (GLP-1) influences taste preference. Fourteen healthy participants (six male and eight female) were included in this double-blind, placebo-controlled crossover study. After overnight fast and salty fluid (oral sodium load), participants were randomized to receive placebo (500 mL of 0.9% saline) or GLP-1 infusion (1.5 pmol/kg/min) over a 3-hour period. At the end of infusion, participants chose food preferences from illustrations of food types representing 5 tastes. After 7 days, the protocol was repeated, this time those that had received placebo first got GLP-1 infusion, and those having received GLP-1 first got placebo. Change of taste preference after GLP-1 infusion but not after placebo was reported as response, and non-response was reported in case of taste persistence. A statistically significant difference in response type was found between genders, with women being more likely to change their taste preference after GLP-1 than men. The change of taste upon GLP-1 infusion observed in women might be ascribed to estrogen weight-lowering effects accomplished by receptor-mediated delivery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee04b2d4aa40cbd55b914e5fc9a8c820Test
https://pubmed.ncbi.nlm.nih.gov/31819319Test

المؤلفون: Maja Bogdanić, Tatjana Vilibić-Čavlek, Nataša Beader, Branko Kolarić, Irena Tabain

المصدر: Acta clinica Croatica
Volume 56
Issue 2.
Acta Clinica Croatica, Vol 56, Iss 2., Pp 255-261 (2017)

مصطلحات موضوعية: Male, Herpesvirus 4, Human, medicine.medical_treatment, viruses, 030232 urology & nephrology, lcsh:Medicine, Cytomegalovirus, 030230 surgery, BIOMEDICINE AND HEALTHCARE. Public Health and Health Care. Epidemiology, medicine.disease_cause, Gastroenterology, Immunoglobulin G, Serology, 0302 clinical medicine, Seroepidemiologic Studies, Prevalence, Renal dialysis, Herpesviridae, biology, Herpesvirus 3, human, Herpesvirus 1, human, General Medicine, Herpesviridae Infections, Hemodijaliza, Middle Aged, Cytomegalovirus Infections, Female, Hemodialysis, Adult, medicine.medical_specialty, Croatia, Hrvatska, Congenital cytomegalovirus infection, Herpesvirus 3, humani, Enzyme-Linked Immunosorbent Assay, Herpesvirus 1, humani, Virus, 03 medical and health sciences, Immunocompromised Host, Renal Dialysis, Internal medicine, medicine, Seroprevalence, Humans, business.industry, lcsh:R, Herpes simplex virus, Varicella-zoster virus, Epstein-barr virus, BIOMEDICINA I ZDRAVSTVO. Javno zdravstvo i zdravstvena zaštita. Epidemiologija, medicine.disease, Virology, Citomegalovirus, herpesvirus 4, humani, biology.protein, business, Cytomegalovirus, herpesvirus 4, human

الوصف: Virusi iz herpes grupe (herpes simpleks virus, HSV; varičela-zoster virus, VZV; citomegalovirus, CMV; Epstein-Barrov virus, EBV) su značajan uzrok smrtnosti u imunokompromitiranih osoba. Cilj rada bio je analizirati učestalost HSV-1, HSV-2, VZV, CMV i EBV u bolesnika koji se liječe hemodijalizom. Tijekom trogodišnjeg razdoblja (2013.-2015.) ispitano je ukupno 152 uzastopno pristiglih uzoraka seruma bolesnika na hemodijalizi te 150 uzoraka seruma zdravih osoba (kontrolna skupina) na prisutnost herpes virusnih IgM/IgG protutijela. Serološko testiranje učinjeno je pomoću komercijalnog dijagnostičkog imunoenzimnog testa (ELISA) ili imunoenzimnog testa s fluorescentnom detekcijom (ELFA). Bolesnici na hemodijalizi bili su značajno češće CMV IgG seropozitivni u odnosu na kontrolnu skupinu (88,2% prema 78,7%, p=0,011). Nadalje, seroprevalencija HSV-1 i VZV također je bila viša u bolesnika na hemodijalizi, no statistička značajnost nije dostignuta (85,5% prema 80,0%, p=0,054; 99,3% prema 96,0%, p=0,051). Učestalost HSV-2 i EBV protutijela nije se razlikovala između skupina (12,5% prema 12,7%, p=0,137, odnosno 98,0% prema 95,3%, p=0,113). IgG seroprevalencija nije se razlikovala u odnosu na spol i mjesto prebivališta. Rezultati logističke regresije pokazali su da je starija životna dob značajan čimbenik rizika za CMV i EBV seropozitivnost (porastom dobi za jednu godinu CMV OR=1,055; 95%CI=1,030-1,080; EBV OR=1,075, 95%CI=1,023-1,130). Herpes group viruses (herpes simplex virus, HSV; varicella-zoster virus, VZV; cytomegalovirus, CMV; and Epstein-Barr virus, EBV) remain an important cause of morbidity in immunocompromised persons. The aim of the study was to analyze the prevalence of HSV-1, HSV-2, VZV, CMV and EBV in patients undergoing hemodialysis. During a three-year period (2013-2015), 152 consecutive serum samples from hemodialysis patients and 150 healthy subjects (control group) were tested for the presence of IgM/IgG antibodies to herpes group viruses. Serologic tests were performed using a commercial enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunofluorescent assay (ELFA). Hemodialysis patients showed significantly higher CMV IgG seropositivity compared to controls (88.2% vs. 78.7%, p=0.011). In addition, seroprevalence rates of HSV-1 and VZV were higher in hemodialysis patients; however, these differences did not reach statistical significance (85.5% vs. 80.0%, p=0.054 and 99.3% vs. 96.0%, p=0.051, respectively). The prevalence of HSV-2 and EBV was similar in both groups (12.5% vs. 12.7%, p=0.137 and 98.0% vs. 95.3%, p=0.113, respectively). There was no difference in IgG seropositivity according to gender and place of residence. Logistic regression showed that older age was a significant predictor for CMV and EBV IgG seropositivity (increase in age by one year: CMV OR=1.055; 95%CI=1.030-1.080 and EBV OR=1.075, 95%CI=1.023-1.130).

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646ca838ef18763c2418d9213a1674cfTest
https://pubmed.ncbi.nlm.nih.gov/29485792Test