دورية أكاديمية
Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
| العنوان: | Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study |
|---|---|
| المؤلفون: | Papadimitriou, N, Bull, CJ, Jenab, M, Hughes, DJ, Bell, JA, Sanderson, E, Timpson, NJ, Smith, GD, Albanes, D, Campbell, PT, Küry, S, Le Marchand, L, Ulrich, CM, Visvanathan, K, Figueiredo, JC, Newcomb, PA, Pai, RK, Peters, U, Tsilidis, KK, Boer, JMA, Vincent, EE, Mariosa, D, Gunter, MJ, Richardson, TG, Murphy, N |
| المصدر: | 10 ; 1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| جغرافية الموضوع: | England |
| الوصف: | BACKGROUND: Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colorectal cancer risk. METHODS: We conducted Mendelian randomization (MR) analyses to investigate potential causal relationships between self-perceived body size (thinner, plumper, or about average) in early life (age 10) and measured body mass index in adulthood (mean age 56.5) with risk of colorectal cancer. The total and independent effects of body size exposures were estimated using univariable and multivariable MR, respectively. Summary data were obtained from a genome-wide association study of 453,169 participants in UK Biobank for body size and from a genome-wide association study meta-analysis of three colorectal cancer consortia of 125,478 participants. RESULTS: Genetically predicted early life body size was estimated to increase odds of colorectal cancer (odds ratio [OR] per category change: 1.12, 95% confidence interval [CI]: 0.98-1.27), with stronger results for colon cancer (OR: 1.16, 95% CI: 1.00-1.35), and distal colon cancer (OR: 1.25, 95% CI: 1.04-1.51). After accounting for adult body size using multivariable MR, effect estimates for early life body size were attenuated towards the null for colorectal cancer (OR: 0.97, 95% CI: 0.77-1.22) and colon cancer (OR: 0.97, 95% CI: 0.76-1.25), while the estimate for distal colon cancer was of similar magnitude but more imprecise (OR: 1.27, 95% CI: 0.90-1.77). Genetically predicted adult life body size was estimated to increase odds of colorectal (OR: 1.27, 95% CI: 1.03, 1.57), colon (OR: 1.32, 95% CI: 1.05, 1.67), and proximal colon (OR: 1.57, 95% CI: 1.21, 2.05). CONCLUSIONS: Our findings suggest that the positive association between early life body size and colorectal cancer risk is likely due to large body size retainment into adulthood. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-7015 |
| العلاقة: | BMC Medicine; http://hdl.handle.net/10044/1/102442Test |
| DOI: | 10.1186/s12916-022-02702-9 |
| الإتاحة: | https://doi.org/10.1186/s12916-022-02702-9Test http://hdl.handle.net/10044/1/102442Test |
| حقوق: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0Test/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.A19A8CB4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17417015 |
|---|---|
| DOI: | 10.1186/s12916-022-02702-9 |