دورية
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
| العنوان: | Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress |
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| المؤلفون: | Forrellad, Marina A., Vázquez, Cristina L., Blanco, Federico C., Klepp, Laura I., García, Elizabeth A., Rocha, Rosana V., Luciana, Villafañe, Bigi, María M., Gutierrez, Maximiliano G., Bigi, Fabiana |
| المصدر: | Virulence; January 2019, Vol. 10 Issue: 1 p1026-1033, 8p |
| مستخلص: | ABSTRACTIn this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosiscomplex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a protein linked to nitrosative stress. Here, we showed that knockout of the Rv2617cgene in M. tuberculosisCDC1551 reduced the replication of the pathogen in a mouse model of infection and favored the trafficking of mycobacteria to phagolysosomes. We also demonstrated that Rv2617c and P36 are required for resistance to in vitrohydrogen peroxide treatment in M. tuberculosisand Mycobacterium bovis, respectively. These findings indicate Rv2617c and P36 act in concert to prevent bacterial damage upon oxidative stress. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2019.1693714 |