Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study
| العنوان: | Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study |
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| المؤلفون: | Doyon, Anke, Haas, Pascal, Erdem, Sevcan, Ranchin, Bruno, Kassai, Behrouz, Mencarelli, Francesca, Lugani, Francesca, Harambat, Jerome, Matteucci, Maria Chiara, Chinali, Marcello, Habbig, Sandra, Zaloszyc, Ariane, Testa, Sara, Vidal, Enrico, Gimpel, Charlotte, Azukaitis, Karolis, Kovacevic, Alexander, Querfeld, Uwe, Schaefer, Franz |
| المساهمون: | Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Hôpital de Hautepierre [Strasbourg] |
| المصدر: | Scientific Reports Scientific Reports, 2019, 9 (1), pp.11462. ⟨10.1038/s41598-019-46653-3⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific reports, London : Nature Publishing Group, 2019, vol. 9, art. no. 11462, p. [1-9] Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.11462. ⟨10.1038/s41598-019-46653-3⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Adolescent, Systole, Heart Ventricles, lcsh:Medicine, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Article, Ventricular Function, Left, Ventricular Dysfunction, Left, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diastole, Chronic kidney disease, Humans, Prospective Studies, Child, lcsh:Science, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Carotid artery disease, lcsh:R, Atherosclerosis, Echocardiography, Doppler, Hypertension, cardiovascular system, Kidney Failure, Chronic, Female, Hypertrophy, Left Ventricular, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, tissue doppler-echocardiography, European-society, heart-failure, dysfunction |
| الوصف: | International audience; Children with chronic kidney disease suffer from excessive cardiovascular mortality and early alterations of the cardiovascular system. Tissue doppler imaging is a validated echocardiographic tool to assess early systolic and diastolic cardiac dysfunction. We hypothesized that tissue Doppler velocities would reveal reduced cardiac function in children with chronic kidney disease compared to healthy children. A standardized echocardiographic exam was performed in 128 patients of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) Study aged 6-17 years with an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m(2). Tissue Doppler measurements included early (E') and late (A') diastolic and systolic (S') velocity at the mitral and septal annulus of the left ventricle. Measured values were normalized to z-scores using published reference data. Predictors of E'/A', E/E', S' and left ventricular mass index (LVMI) were assessed by multiple linear regression analyses. Tissue Doppler E' was reduced and tissue Doppler A' increased, resulting in a reduced tissue Doppler E'/A' ratio (z-score -0.14, p < 0.0001) indicating reduced diastolic function compared to healthy children. Reduced tissue Doppler E'/A' Z-Scores were independently associated with lower eGFR (p = 0.002) and increased systolic blood pressure (p = 0.02). While E/E' Z-Scores were increased (Z-score 0.57, p < 0.0001), patients treated with pharmacological RAS blockade but not with other antihypertensive treatments had significantly lower E/E' and higher E'/A' Z-Scores. Systolic tissue Doppler velocities were significantly decreased (Z-score -0.24, p = 0.001) and inversely correlated with E/E' Z-Scores (r = -0.41, p < 0.0001). LVMI was not associated with systolic or diastolic tissue Doppler velocities. Concentric left ventricular hypertrophy showed a tendency to lower S' in multivariate analysis (p = 0.13) but no association to diastolic function. Concentric left ventricular geometry was significantly associated with lower midwall fractional shortening. In summary, systolic and diastolic function assessed by tissue Doppler is impaired. eGFR, systolic blood pressure and the type of antihypertensive medications are significant predictors of diastolic function in children with CKD. Left ventricular morphology is largely independent of tissue Doppler velocities. Tissue Doppler velocities provide sensitive information about early left ventricular dysfunction in this population. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::002a97b8f77a6b6e0c0ac30da230d001Test https://hal.science/hal-03169062/file/BPH_SR_2019_Doyon.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....002a97b8f77a6b6e0c0ac30da230d001 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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