دورية أكاديمية
Liver cancer mortality over six decades in an epidemic area: what we have learned
| العنوان: | Liver cancer mortality over six decades in an epidemic area: what we have learned |
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| المؤلفون: | Chen, Jian-Guo, Zhu, Jian, Zhang, Yong-Hui, Chen, Yong-Sheng, Lu, Jian-Hua, Zhu, Yuan-Rong, Chen, Hai-Zhen, Shen, Ai-Guo, Wang, Gao-Ren, Groopman, John D., Kensler, Thomas W. |
| المساهمون: | The US National Institutes of Health, The Chinese National Key Projects, The Scientifc Research Projet of “333 Project” in Jiangsu, The Nantong Science and Technology Project |
| المصدر: | PeerJ ; volume 9, page e10600 ; ISSN 2167-8359 |
| بيانات النشر: | PeerJ |
| سنة النشر: | 2021 |
| المجموعة: | PeerJ (E-Journal - via CrossRef) |
| الوصف: | Background and aims: Liver cancer is one of the most dominant malignant tumors in the world. The trends of liver cancer mortality over the past six decades have been tracked in the epidemic region of Qidong, China. Using epidemiological tools, we explore the dynamic changes in age-standardized rates to characterize important aspects of liver cancer etiology and prevention. Methods Mortality data of liver cancer in Qidong from 1958 to 1971 (death retrospective survey) and from 1972 to 2017 (cancer registration) were tabulated for the crude rate (CR), and age-standardized rate and age-birth cohorts. The average annual percentage change was calculated by the Joinpoint Regression Program. Results The natural death rate during 1958–2017 decreased from 9‰ to 5.4‰ and then increased to 8‰ as the population aged; cancer mortality rates rose continuously from 57/10 5 to 240/10 5 . Liver cancer mortality increased from 20/10 5 to 80/10 5 , and then dropped to less than 52/10 5 in 2017. Liver cancer deaths in 1972–2017 accounted for 30.53% of all cancers, with a CR of 60.48/10 5 , age-standardized rate China (ASRC) of 34.78/10 5 , and ASRW (world) of 45.71/10 5 . Other key features were the CR for males and females of 91.86/10 5 and 29.92/10 5 , respectively, with a sex ratio of 3.07:1. Period analysis showed that the ASRs for mortality of the age groups under 54 years old had a significant decreasing trend. Importantly, birth cohort analysis showed that the mortality rate of liver cancer in 40–44, 35–39, 30–34, 25–29, 20–24, 15–19 years cohort decreased considerably, but the rates in 70–74, and 75+ increased. Conclusions The crude mortality rate of liver cancer in Qidong has experienced trends from lower to higher levels, and from continued increase at a high plateau to most recently a gradual decline, and a change greatest in younger people. Many years of comprehensive prevention and intervention measures have influenced the decline of the liver cancer epidemic in this area. The reduction of intake levels of aflatoxin ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7717/peerj.10600 |
| الإتاحة: | https://doi.org/10.7717/peerj.10600Test https://peerj.com/articles/10600.pdfTest https://peerj.com/articles/10600.xmlTest https://peerj.com/articles/10600.htmlTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.63A1AB0B |
| قاعدة البيانات: | BASE |
| DOI: | 10.7717/peerj.10600 |
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