دورية أكاديمية
Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019
| العنوان: | Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019 |
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| المؤلفون: | Jin, Yujiao, Wang, Miaochan, Zuo, Zhongbao, Fan, Chaoming, Ye, Fei, Cai, Zhaobin, Wang, Ying, Cui, Huaizhong, Pan, Kenu, Xu, Aifang |
| المصدر: | reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano |
| بيانات النشر: | Science Direct |
| سنة النشر: | 2020 |
| المجموعة: | Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO) |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, Diagnosis, Serological test, Immunoglobulin M, Immunoglobulin G, Síndrome respiratorio agudo grave, Coronavirus |
| الوصف: | Objective: To investigate the diagnostic value of serological testing and dynamic variance of serum antibody in coronavirus disease 2019 (COVID-19). Methods: This study retrospectively included 43 patients with a laboratory-confirmed infection and 33 patients with a suspected infection, in whom the disease was eventually excluded. The IgM/IgG titer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was measured by chemiluminescence immunoassay analysis. Results: Compared to molecular detection, the sensitivities of serum IgM and IgG antibodies to diagnose COVID-19 were 48.1% and 88.9%, and the specificities were 100% and 90.9%, respectively.In the COVID-19 group, the IgM-positive rate increased slightly at first and then decreased over time; in contrast, the IgGpositive rate increased to 100% and was higher than IgM at all times. The IgM-positive rate and titer were not significantly different before and after conversion to virus-negative. The IgG-positive rate was up to 90% and not significantly different before and after conversion to virus-negative. However, the median IgG titer after conversion to virus-negative was double that before, and the difference was significant. Conclusions: Viral serological testing is an effective means of diagnosis for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than those of IgM in COVID-19. © 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 4 páginas; application/pdf |
| اللغة: | unknown |
| تدمد: | 1201-9712 |
| العلاقة: | https://doi.org/10.1016/j.ijid.2020.03.065Test; http://hdl.handle.net/20.500.12010/10797Test |
| DOI: | 10.1016/j.ijid.2020.03.065 |
| الإتاحة: | https://doi.org/20.500.12010/10797Test https://doi.org/10.1016/j.ijid.2020.03.065Test https://hdl.handle.net/20.500.12010/10797Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8E79D120 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 12019712 |
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| DOI: | 10.1016/j.ijid.2020.03.065 |