دورية أكاديمية
Anti-seizure medication tapering is associated with delta band power reduction in a dose, region and time-dependent manner ...
| العنوان: | Anti-seizure medication tapering is associated with delta band power reduction in a dose, region and time-dependent manner ... |
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| المؤلفون: | Besne, Guillermo M., Evans, Nathan, Panagiotopoulou, Mariella, Smith, Billy, Chowdhury, Fahmida A, Diehl, Beate, Duncan, John S, McEvoy, Andrew W, Miserocchi, Anna, de Tisi, Jane, Walker, Mathew, Taylor, Peter N., Thornton, Chris, Wang, Yujiang |
| بيانات النشر: | arXiv |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Neurons and Cognition q-bio.NC, FOS Biological sciences |
| الوصف: | Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice. We examined over 3000 hours of intracranial EEG recordings in 32 subjects during long-term monitoring, of which 22 underwent concurrent ASM tapering. We estimated ASM plasma levels based on known pharmaco-kinetics of all the major ASM types. We found an overall decrease in the power of delta band activity around the period of maximum medication withdrawal in most (80%) subjects, independent of their epilepsy type or medication combination. The degree of withdrawal correlated positively with the magnitude of delta power decrease. This dose-dependent effect was strongly seen across all recorded cortical regions during daytime; but not in sub-cortical regions, or during night time. We found no evidence of differential effect in seizure onset, spiking, or pathological brain ... |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | unknown |
| DOI: | 10.48550/arxiv.2405.01385 |
| الإتاحة: | https://doi.org/10.48550/arxiv.2405.01385Test https://arxiv.org/abs/2405.01385Test |
| حقوق: | arXiv.org perpetual, non-exclusive license ; http://arxiv.org/licenses/nonexclusive-distrib/1.0Test/ |
| رقم الانضمام: | edsbas.71B24CD3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.48550/arxiv.2405.01385 |
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