التفاصيل البيبلوغرافية
| العنوان: |
Granulocytic myeloid-derived suppressor cells inversely correlate with plasma arginine and overall survival in critically ill patients. |
| المؤلفون: |
Gey, A., Tadie, J.‐M., Caumont‐Prim, A., Hauw‐Berlemont, C., Cynober, L., Fagon, J.‐Y., Terme, M, Diehl, J.‐L., Delclaux, C., Tartour, E. |
| المصدر: |
Clinical & Experimental Immunology; May2015, Vol. 180 Issue 2, p280-288, 9p |
| مصطلحات موضوعية: |
IMMUNOSUPPRESSION, ARGININE, SUPPRESSOR cells, NITRIC oxide, INTERLEUKIN-10, PATIENTS |
| مستخلص: |
Critically ill patients display a state of immunosuppression that has been attributed in part to decreased plasma arginine concentrations. However, we and other authors have failed to demonstrate a clinical benefit of L-arginine supplementation. We hypothesize that, in these critically ill patients, these low plasma arginine levels may be secondary to the presence of granulocytic myeloid-derived suppressor cells ( gMDSC), which express arginase known to convert arginine into nitric oxide ( NO) and citrulline. Indeed, in a series of 28 non-surgical critically ill patients, we showed a dramatic increase in gMDSC compared to healthy subjects ( P = 0·0002). A significant inverse correlation was observed between arginine levels and gMDSC ( P = 0·01). As expected, gMDSC expressed arginase preferentially in these patients. Patients with high gMDSC levels on admission to the medical intensive care unit ( MICU) presented an increased risk of death at day 7 after admission ( P = 0·02). In contrast, neither plasma arginine levels, monocytic MDSC levels nor neutrophil levels were associated with overall survival at day 7. No relationship was found between body mass index ( BMI) or simplified acute physiology score (SAPS) score, sequential organ failure assessment (SOFA) score or gMDSC levels, eliminating a possible bias concerning the direct prognostic role of these cells. As gMDSC exert their immunosuppressive activity via multiple mechanisms [production of prostaglandin E2 ( PGE2), interleukin ( IL)-10, arginase, etc.], it may be more relevant to target these cells, rather than simply supplementing with L-arginine to improve immunosuppression and its clinical consequences observed in critically ill patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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